Acenocoumarol in Geriatric Population
نویسندگان
چکیده
Abhijit Trailokya1* and Amit Bahulayan2 1Chief Medical Advisor, Medical Services Division, Abbott Healthcare Private Limited, Mumbai, India 2MSL, Medical Department, Abbott Healthcare Private Limited, Mumbai, India *Corresponding author: Abhijit Trailokya, MBBS, Geriatric Medicine, Pharmaceutical Medicine, Chief Manager, Medical Advisor, Medical Services Division, Abbott Healthcare Private Limited, Mulund, Mumbai 400 080, India, Tel: 8080042460; E-mail: [email protected]
منابع مشابه
Therapeutic Dosing of Acenocoumarol: Proposal of a Population Specific Pharmacogenetic Dosing Algorithm and Its Validation in North Indians
OBJECTIVES To develop a population specific pharmacogenetic acenocoumarol dosing algorithm for north Indian patients and show its efficiency in dosage prediction. METHODS Multiple and linear stepwise regression analyses were used to include age, sex, height, weight, body surface area, smoking status, VKORC1 -1639 G>A, CYP4F2 1347 G>A, CYP2C9*2,*3 and GGCX 12970 C>G polymorphisms as variables ...
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BACKGROUND & OBJECTIVES CYP4F2 and γ-glutamyl carboxylase (GGCX) have small but significant roles in the maintenance dose of coumarinic oral anticoagulants (COAs). CYP4F2 1347 G > A and GGCX 12970 C > G polymorphisms have been used in the pharmacogenetic dosing algorithms of warfarin for Caucasians and Chinese populations. India has a large population with multiple ethnic groups but there are n...
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A study was carried out to evaluate the potential pharmacokinetic interaction between digoxin and acenocoumarol. The binding of digoxin to rabbit cardiac tissue homogenates was assessed in vitro, using the equilibrium dialysis technique. An increase in the first-order constant (p<0.05) and a reduction in the partition coefficient in the equilibrium situation (p<0.001) of digoxin were observed w...
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The oral anticoagulant acenocoumarol is given as a racemic mixture. The (S)-enantiomer is rapidly cleared and is the reason why only (R)-acenocoumarol contributes to the pharmacological effect. The objective of the study was to establish the cytochrome P450 (CYP) enzymes catalyzing the hydroxylations of the acenocoumarol enantiomers. Of various cDNA-expressed human CYPs, only CYP2C9 hydroxylate...
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